🫀 5. Proton Pump Inhibitors (PPIs)
5. Proton
Pump Inhibitors (PPIs)
Examples: Prilosec, Nexium, Prevacid
Used for: Acid reflux, GERD
What Research Suggests
Some studies have reported a possible association between long-term PPI use and dementia risk, although findings remain mixed and inconclusive.Save on Rx
What to Do
Ask your doctor whether:
A lower dose is appropriate
Shorter treatment duration may help
Alternatives such as H2 blockers (for example, famotidine) are suitable
💧 6. Overactive Bladder Medications
Examples
Oxybutynin (highest concern)
Tolterodine
Solifenacin
What to Do
Discuss possible alternatives, including:
Mirabegron
Pelvic floor therapy
Bladder training exercises
🤧 7.
First-Generation Antihistamines
Examples
Diphenhydramine (Benadryl)
Chlorpheniramine
Hydroxyzine
Doxylamine
What Research Suggests
Long-termuse has been associated with cognitive decline because these medications can affect brain signaling pathways.
What to Do
Ask about newer antihistamines that may have lower cognitive risk, such as:
Cetirizine
Loratadine
Fexofenadine
🧠 8. Statins (Controversial)
🧠 8. Statins (Controversial)
Used for: High cholesterol
What Research Shows
Large clinical trials have generally found no significant evidence of cognitive harm from statins. Their cardiovascular benefits remain well established.
